EPCO-09. TRANSCRIPTOMIC LANDSCAPE OF LOWER GRADE GLIOMA BASED ON AGE-RELATED NON-SILENT SOMATIC MUTATIONS

Abstract Glioma accounts for 80% of all malignant brain tumours and is the most common adult primary tumour. Age an important factor affecting development cancer, as somatic mutations accumulate with age. Here, we aimed to analyse significance age-dependent non-silent in glioma prognosis. Histological tumour grade depends on age at diagnosis patients IDH1, TP53, ATRX, EGFR mutations. wild-type IDH1 increased increase grade, while or mutation remained constant. However, was higher than that mutation. The hierarchical clustering dominantly separated by Furthermore, were TP53 ATRX double its counterpart. lower TP53. Patients showed poorer prognosis those wild type genotype. Unlike mutant, upregulation expression epithelial mesenchymal transition associated genes.